As a veterinarian, one of the most common issues I see in my clinic is periodontal disease. It's heartbreaking because it is entirely preventable, yet so many pups suffer in silence. While daily brushing is the gold standard, I know life gets busy. That is where dental chews come in—they are a fantastic, practical supplement to your dog's oral hygiene routine.
Today, I am comparing two heavyweights in the dental treat aisle: the widely accessible Pedigree Dentastix Large Breed Dog Treats and the premium, natural Greenies Blueberry Dental Dog Treats. We are looking at a classic budget-friendly option versus a specialized, flavor-forward formula. Whether you have a large breed that needs a sturdy chew or a medium-sized pup with a taste for fruit, this guide will help you decide which one belongs in your pantry.
Our Top Pick
Greenies
Greenies Blueberry Dental Dog Treats 12oz
If you prioritize ingredient quality and digestibility, Greenies Blueberry Dental Dog Treats are the superior choice. Their natural formulation and flexible texture provide a deep clean that is gentle on sensitive stomachs. However, if you have a large dog and need a cost-effective daily solution, Pedigree Dentastix offers unbeatable value while still effectively reducing tartar buildup through its clever X-shape design.
When we look at what goes into our dogs' bodies, the difference between these two brands becomes distinct. Greenies Blueberry Dental Dog Treats shine here with a focus on natural ingredients. They are formulated to be highly soluble, meaning they break down easily in the digestive tract. This is a crucial factor if your dog is prone to tummy trouble or if you worry about intestinal blockages. The addition of blueberry adds a lovely flavor twist and provides a source of antioxidants, making it feel like a wholesome reward rather than just a tool.
| Feature | Pedigree Dentastix Large Breed | Greenies Blueberry (Regular) |
|---|---|---|
| Our Score | 9.8/10 | 9.8/10 |
| Best For | Large Breeds (40+ lbs) | Medium Dogs (25-50 lbs) |
| Primary Ingredient Focus | Chicken Flavor, Functional | Natural Ingredients, Blueberry |
| Texture/Design | X-Shape, rigid | Chewy, flexible, toothbrush shape |
| Pack Size | 32 Count | 12 Count (12oz) |
| Approx. Price | $14.79 | $17.90 |
| Price Per Treat | ~$0.46 | ~$1.49 |
Pedigree Dentastix, on the other hand, focuses on functionality. While they contain no added sugar—which I appreciate—they are a more traditional commercial treat. They rely on a chicken flavor that is highly palatable for most dogs, but the ingredient list is generally less "clean" than Greenies. If you are a pet parent who strictly monitors grain sources or fillers, Greenies is the safer bet.

The mechanism of action is quite different between these two. Pedigree focuses on mechanical scraping, while other brands might focus on enzymatic action or texture-based cleaning.
Why does solubility matter in dental chews? expand_more
Solubility refers to how quickly a treat breaks down when exposed to liquid (like stomach acid). Highly soluble treats, like Greenies, reduce the risk of digestive obstruction, making them a safer choice for dogs who tend to gulp their food rather than chew thoroughly.
Cleaning Power: Pedigree's X-Shape vs Greenies' Texture
Pedigree Dentastix features a unique X-shape cross-section. This isn't just for looks; it is designed to shear against the tooth surface as the dog chews, helping to scrape away plaque. It is particularly good for reaching those back molars in large dogs. The texture is firm, requiring a good amount of mechanical force to break down, which stimulates the gums.
Watch: Pedigree Dentastix Large Breed Dog Treats, 32 Count
Greenies utilize a flexible, chewy texture that allows the dog's teeth to sink into the treat up to the gumline before the treat breaks off. This "brushing" action is clinically proven to reduce tartar by 47% in 28 days. Because the texture is softer and more pliable, it effectively scrubs the entire surface of the tooth rather than just scraping the high points.
Value Analysis: Cost Per Treat
For many families, budget is a deciding factor, especially for a product meant to be given daily. Here, Pedigree Dentastix is the undisputed winner in terms of pure economics. At approximately $0.46 per treat, Pedigree allows you to maintain a daily dental hygiene routine for a large dog for under $15 a month. This accessibility is vital because dental care only works if it is consistent.

Greenies Blueberry, while excellent, come in at a premium price of roughly $1.49 per treat. That is nearly three times the cost. You are paying for the natural ingredients, the specialized manufacturing process, and the blueberry formulation. For a 12-count bag, you are looking at less than two weeks of supply. If you have multiple dogs, this cost can add up quickly.
| If you want... | Choose This Product |
|---|---|
| The most budget-friendly option | Pedigree Dentastix |
| Natural ingredients & digestibility | Greenies Blueberry |
| Treats for a Large Breed (50lb+) | Pedigree Dentastix |
| Treats for a Medium Dog (25-40lb) | Greenies Blueberry |
| A novel flavor (non-meat) | Greenies Blueberry |
| Maximum quantity per bag | Pedigree Dentastix |
Final Verdict: Which Chew Should You Choose?
Both of these products are effective tools in the fight against canine periodontal disease, but they serve different needs. Ultimately, the best dental chew is the one your dog enjoys enough to chew on long enough to do the work—and the one that fits your budget well enough to give consistently.
Watch: Greenies Blueberry Dental Dog Treats 12oz
Choose Pedigree Dentastix Large Breed if:
- You have a large dog (over 40 lbs) and want a treat sized appropriately for their jaw.
- You need a budget-friendly solution to ensure your dog gets a dental cleaning every single day.
- Your dog prefers savory, traditional chicken flavors over fruit or vegetable notes.
- Your dog falls in the 25-50 lbs weight range.
- You prioritize natural ingredients and easy digestibility for a sensitive stomach.
- You are looking for a "high-value" reward that offers a break from standard meat flavors.
- You want the peace of mind that comes with a clinically proven reduction in tartar.


